Chapter 3: Tenacity was required to Solve the Problem of Drug Content and Concentration Control Drug release speed is determined by the complex relationships between the type of adhesive used, the thickness of the adhesive coating, and the content and concentration of drug contained in the adhesive. In order to realize this goal, however, it is necessary to achieve precision control of drug release speed. If a drug delivery system could be developed that was able to deliver the optimum amount of medication at that time (a smart drug delivery system), then it would be possible to dramatically increase the quality of life of asthma sufferers. In many cases, asthma attacks occur at set times, such as in the early morning. The developers wanted to develop a more advanced product that was able to deliver the required drug dosage at the right time for use in the treatment of asthma. With conventional transdermal formulations, drugs were continuously in the body for long periods of time. By 1983 we had already developed a transdermal patch for preventing the onset of angina. The mechanism whereby drugs are delivered to the body through the transdermal patch.ĭesigning transdermal patches is one area in which Nitto Denko has a great deal of expertise. The development of these patches, however, took 11 years and was full of challenges. This means that users can control asthma attacks, which frequently occur in the early morning, and that the burden on caregivers is also greatly reduced. Unlike conventional oral and inhaled formulations, Hokunalin® Tape has the advantage of being able to appropriately control the concentration of the drug in the body. This is in effect the same as using an injection, but without requiring the use of a needle. When the patch is applied to the skin, the drug penetrates the skin and is absorbed into the blood stream through the capillaries to flow throughout the body. The adhesive layer of the tape contains tulobuterol, a drug that dilates the bronchial tubes making it easier for asthma sufferers to breathe. With each new patch, remove the old patch and change application sites according to your product’s instruction sheet.Ĭhapter 1: World’s First Transdermal Patch for Treatment of Asthma The Hokunalin® Tape jointly developed in 1988 by Abbott Japan Co., Ltd and Nitto Denko was the world's first transdermal patch for treatment of asthma. Wear the patch for the amount of time directed by your doctor. It is important to dispose of used patches and packaging properly. Even a used patch may contain enough drug to harm others, especially children and pets.
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